Septin

基本解釋

Septin 1 is Aurora-B’s substrate in vivo, they two both take part in the regulation of cytokinesis.
Septin1是Aik2的細(xì)胞內(nèi)底物，二者共同參與調(diào)控胞質(zhì)分裂。
Aurora-B can phosphorylate Septin 1.Ser-307 and Ser-315 is its important sites of phosphorylation.
Aik2可磷酸化 Septin1，Ser-307、315是重要的磷酸化位點(diǎn)。
In vivo Location demonstrated that Septin 1 is located in centriole before mitosis, and later slowly moved to the milieu of nucleus.
細(xì)胞內(nèi)定位顯示：Septin1 在有絲分裂前定位于中心粒，后慢慢遷移至核周圍。
Recently, more and more data suggest that some septin family members participate in the pathogenesis of different diseases including neoplasia, neurodegeneration and infections.
更引起研究人員重視的是: 最近有大量數(shù)據(jù)表明, 這一家族的一些成員與腫瘤發(fā)生、神經(jīng)功能障礙和病原微生物感染的過程直接相關(guān)。
After Septin 1 is phosphorylated, it can enhance the kinase’s activity by feedback effect, however we found on such feedback effect in mutant of Septin 1.
Septin1被磷酸化后可反饋性地增強(qiáng)激酶活性，而突變體則沒有這種反饋性的效應(yīng)。