Aceclofenac

常見例句

• Objective To prepare aceclofenac pellet(AFP).
  目的 制備醋氯芬酸微丸。
• Aceclofenac was synthesized in 82% overall yield from sodium diclofenac and t-butyl chloroacetate viaesterification and hydrolysis.
  雙氯芬酸鈉與氯乙酸叔丁酯經(jīng)酯化、水解反應(yīng)制得非甾體抗炎藥醋氯芬酸,收率82%25。
• OBJECTIVE：To study the therapeutic effect on adjuvant-induced arthritis and inhibitory effect on delayed type hypersensitivity(DTH) of aceclofenac.
  目的：研究醋氯芬酸對(duì)佐劑關(guān)節(jié)炎大鼠的治療作用及對(duì)遲發(fā)型超敏反應(yīng)的抑制作用。
• Aceclofenac also suppressed DTH with SRBC or PC in mice when it was administered after antigen challenge,but it had no marked effect when administered before antigon challege.
  醋氯芬酸于抗原攻擊后給藥，顯著抑制SRBC或PC所致小鼠遲發(fā)型超敏反應(yīng)，而抗原攻擊前給藥則無明顯作用。
• Method:Aceclofenac was synthesized from chloroacetic acid and benzyl alcohol by esterification to give benzyl chloroacetate,which subjected to condensation and hydrogenolysis.
  方法:以氯乙酸為原料,和苯甲醇進(jìn)行酯化反應(yīng)合成氯代乙酸芐基酯,再經(jīng)縮合、氫解反應(yīng)制得目標(biāo)化合物。
• CONCLUSION:Aceclofenac exerted marked therapeutic activity against adjuvant-induced arthritis,associated with its inhibiton to inflammatory response and DTH.
  結(jié)論：醋氯芬酸對(duì)大鼠佐劑關(guān)節(jié)炎具有治療作用，其作用機(jī)制可能與其抗炎作用及對(duì)遲發(fā)型超敏反應(yīng)的抑制作用有關(guān)。
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