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It is associated with high perinatal mortality, thick fissured skin, marked ectropion (eyelid eersion), eclabium (eersion of the lips), and flexion deformities. 常伴有圍產(chǎn)期高死亡率、皮膚肥厚、顯著的眼瞼外翻、唇外翻和關(guān)節(jié)彎曲畸形。