notch signaling

基本解釋

This made a prediction that Notch signaling should be active in stem cells and mostly inactive during commitment.
這樣就有一個(gè)預(yù)測(cè)是，Notch信號(hào)在干細(xì)胞中應(yīng)該是有活性的，而在定向的過(guò)程中是幾乎沒有活性的。
Specifically we show that Notch signaling is highly active in hematopoietic stem cells (HSCs), and is critical for maintaining their undifferentiated state.
明確的講我們展示了Notch信號(hào)在造血干細(xì)胞是高度有活性的，而且對(duì)于維持它們的分化狀態(tài)是很關(guān)鍵的。
We set up in collaboration with him and this allowed us to show that Notch signaling was in fact highly enriched in stem cells, and was rapidly shut off as stem cells differentiated.
我們和他進(jìn)行了合作，這就讓我們表明了Notch信號(hào)事實(shí)上在干細(xì)胞中是很多見的，而一旦干細(xì)胞開始分化它就會(huì)中斷了。