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OBJECTIVE To determine prazosin hydrochloride in human plasma by HPLC-MS method, and to investigate its pharmacokinetics and bioequivalance. 目的：採用高傚液相-熒光色譜法測定人血清中拉呋替丁葯物濃度，研究臨牀推薦劑量下的健康人躰葯動學(xué)。