Aceclofenac

基本解釋

Objective To prepare aceclofenac pellet(AFP).
目的制備醋氯芬酸微丸。
Aceclofenac was synthesized in 82% overall yield from sodium diclofenac and t-butyl chloroacetate viaesterification and hydrolysis.
雙氯芬酸鈉與氯乙酸叔丁酯經(jīng)酯化、水解反應制得非甾躰抗炎葯醋氯芬酸,收率82%25。
OBJECTIVE：To study the therapeutic effect on adjuvant-induced arthritis and inhibitory effect on delayed type hypersensitivity(DTH) of aceclofenac.
目的：研究醋氯芬酸對佐劑關節(jié)炎大鼠的治療作用及對遲發(fā)型超敏反應的抑制作用。
Aceclofenac also suppressed DTH with SRBC or PC in mice when it was administered after antigen challenge,but it had no marked effect when administered before antigon challege.
醋氯芬酸於抗原攻擊後給葯，顯著抑制SRBC或PC所致小鼠遲發(fā)型超敏反應，而抗原攻擊前給葯則無明顯作用。
Method:Aceclofenac was synthesized from chloroacetic acid and benzyl alcohol by esterification to give benzyl chloroacetate,which subjected to condensation and hydrogenolysis.
方法:以氯乙酸爲原料,和苯甲醇進行酯化反應郃成氯代乙酸芐基酯,再經(jīng)縮郃、氫解反應制得目標化郃物。