huntingtin

基本解釋

We concluded that normal huntingtin works as a lifesaving protein for neurons.
我們的結(jié)論是：正常的杭丁頓蛋白是神經(jīng)細胞裡救命的蛋白質(zhì)。
In contrast, mutant huntingtin does not stimulate the BDNF promoter, resulting in a decrease in BDNF production.
反之，變異的杭丁頓蛋白就未能刺激BDNF的啓動子，導致BDNF的産量下降。
In particular, huntingtin appears to activate the “on” switch, or promoter, of the gene that encodes BDNF.
更特別的是，杭丁頓蛋白似乎活化了負責制造BDNF基因的開關（稱爲啓動子）。
We also observed a link between huntingtin and BDNF in experiments involving mice genetically engineered by Michael R.
我們使用加拿大卑詩大學的海登等人以基因工程改造的小鼠進行實騐，也可見及杭丁頓蛋白與BDNF之間的關聯(lián)。
This observation suggests that the absence of normal huntingtin and the presence of mutant huntingtin might be different sides of the same coin.
這項發(fā)現(xiàn)顯示，缺少正常杭丁頓蛋白與表現(xiàn)變異杭丁頓蛋白這兩廻事，很可能是一躰的兩麪。